中文摘要：

癫癇猝死系指癫癇患者在发作期或发作间期突发的无法解释的死亡,其风险是普通人群的20余倍。癫癇猝死存在多种机制,与心功能的相关性研究是目前研究的重要课题。癫癇和心脏离子通道病共存的遗传易感性、自主神经功能异常、抗癫癇药物等相关因素导致的心功能异常易诱发癫癇患者发生心源性猝死,进一步了解癫癇猝死发生过程中的心脏病变相关机制能够为制定预防和治疗策略提供理论基础。

英文摘要：

Sudden unexpected death in epilepsy（SUDEP） indicates sudden death without a definitecause in epileptics, especially during seizures or interictal phase. The risk of sudden death in epilepticpatients is over 20 times higher than that in individuals without epilepsy. The explicit pathogenesis ofSUDEP is not clear, while the heart disease is likely to play an important role in SUDEP. Cardiacdysfunction, which is caused by ion channel diseases, autonomic dysfunction, antiepileptic drugs（AEDs）, isassociated with SUDEP. Understanding of the mechanisms about cardiac factors is required to provideeffective strategy for future control of SUDEP.