中文摘要：

为降低近红外脑功能漫射光断层成像（DOT）固有的逆问题病态性，并避免多模态方法的图像配准等问题，提出了基于光学自导引提供先验功能信息的脑功能DOT方法（OT-DOT），并发展了图像重构方法．模拟验证表明：上皮厚度（TLT）已知时，OT-DOT获得的重构量化度（QR）约为传统DOT的4．2倍；当TLT的估计误差小于±10％时，OT-DOT重构的QR值可达92％以上，远远优于传统DOT；噪声鲁棒性测试表明，OT-DOT与传统DOT的噪声鲁棒性相近．利用连续光DOT测量系统的仿体实验重构结果表明，所发展的OT-DOT算法获得的重构结果优于传统DOT算法．

英文摘要：

The image reconstruction of diffuse optical tomography （DOT） for near-infrared brain functional imaging is a severely ill-posed inverse problem. Different from the widely adopted multi-mode imaging method for providing anatomical-prior to DOT, this paper proposed an optical self-guiding scheme, called OT-DOT, and the corresponding image reconstruciton algorithm is developed. The numerical and phantom validations are performed for the proposed method. Numerical reconstruction results indicate that quantitativeness ratio （QR） reconstructed with OT-DOT for the target is about 4.2 times bigger than that with traditional DOT for the known top layer thickness（TLT）. QR from OT-DOT can be more 92% when the estimation error of TLT is less than ± 10%. The noise-robustness testing indicates the reconstruction ability of OT-DOT and traditional DOT are roughly the same. Phantom experiments performed using a continuous-wave DOT system show that the reconstructed results with the proposed method is better than those with traditional DOT.