中文摘要：

许多钌（Ⅱ）配合物在水溶液中可以发生光诱导配体解离,形成的水合物能够与DNA共价结合.Ru（Ⅱ）配合物的这一特性近年来在抗癌药物研发领域被利用来发展新型光活化化疗试剂.通过合理选择配体和调控配位构型,光活化化疗试剂可以实现抗癌活性物种在肿瘤组织的高选择性且计量可控的释放,有希望在提高药物疗效的同时降低其毒副作用.本文对近年来钌（Ⅱ）光活化化疗试剂的研究进展做了全面的综述,并展望了该领域的未来发展方向.

英文摘要：

Many Ru（Ⅱ） complexes can undergo photoinduced ligand dissociation in aqueous solutions, and the formed aqua Ru（Ⅱ） species may bind to DNA covalently. This property has been applied to develop novel photoactivated chemotherapy（PACT） agents for cancer treatment in recent years. By finely tuning ligand structures and coordination configurations, PACT may realize highly selective and on-demand release of active species in cancer tissues, leading to an improved efficacy and diminished side effects. In this review, the progress in Ru（Ⅱ）-based PACT agents was fully discussed and a perspective for their future development was included.