中文摘要：

对天然化合物4-羟甲基-2（5H）-呋喃酮的合成路线进行了改进,采用三羟甲基氨基甲烷盐酸盐为起始原料,经二羟基保护、氧化成酮,再与乙酸乙酯基三苯基膦叶立德反应,脱保护成内酯环合成出4-羟甲基-2（5H）-呋喃酮,总产率为23%。考察了其对铜绿假单胞菌生物膜的影响,结果显示该化合物对细菌生物膜的形成有一定的抑制作用。

英文摘要：

The method for synthesis of the natural compound 4-（hydroxymethyl）-2（5H）-furanone was improved by starting from tris（hydro-xymethyl）aminomethane hydrochloride,via a procedure of protecting two hydroxyl groups and formation of ketone through oxidation,followed by reacting with（ethoxycarbonylmethylene）triphenyl phosphonium ylide,and deprotection and cyclization as lactone.The overall product yield reached 23%.Its effects on pseudomonas aeruginosa biofilm were assayed,and the test results showed that the title compound acted as weak inhibitor on the bacterial biofilm formation.