中文摘要：

阿尔茨海默病（Alzheimer’s disease,AD）为一种神经退行性疾病,是导致成年人痴呆最常见的原因之一。人们对于该病的研究虽历时数百余年,其中Aβ学说、tau学说在AD中的作用得到广泛认可,但是有关AD的具体发病机制仍不十分清楚。可以明确的是,AD是一种多因素引起的疾病,除了遗传、衰老和生活习惯外,环境因素也不容忽视,一些金属元素,如铜、铝、锌和铁等都可能与AD密切相关。本文就这些金属元素与AD的相关研究进行简要概述。

英文摘要：

Alzheimer＇s disease （AD） is a kind of neurodegenerative diseases, the most common cause of dementia. Although AD has been studied more than 100 years and the Aft and tau theory are most widely accepted among the theories achieved, yet it is not really clear what the mechanism related to AD works up to now. However, it is certain that AD is a kind of diseases resulting from multi-causes. Except for causes correlated with heredity, aging and life habits, environmental role is worth taking into consideration as well. Some metals, such as copper, aluminum, zinc and iron et al, can also have close relationship with AD. Now, we make an overview on the correlative researches in the field.