中文摘要：

白细胞介素（IL）-18是一多效能的促炎性细胞因子,是已知的影响Th1/Th2免疫应答失衡的主要细胞因子之一,在免疫调节中具有重要作用。炎症性肠病是一种肠道慢性炎症性疾病,以免疫异常为主要特征。本文将就IL-18及其与IBD关系的研究进展作一综述。

英文摘要：

Interleukin-18 （IL-18） is a pleiotropic and pro-inflammatory cytokine. It is one of the major cytokines that affect Thl/Th2 immune response imbalance, which plays an active role in immunoregulation. Inflammatory bowel disease （IBD） is a chronic inflammation of intestinal, which is characterized by abnormal immune reaction. Progress in the researches of IL-18 and its relationship with IBD was reviewed in the paper.