中文摘要：

目的探讨糖尿病合并高血压患者血糖血压水平与动脉硬化的关系。方法以北京某农村社区40岁及以上糖尿病合并高血压患者为研究对象，对患者进行问卷调查、体格检查、肱踝脉搏波传导速度（baPWV）检测和血样检测。根据患者糖化血红蛋白（HbAlc）、收缩压（SBP）及舒张压（DBP）水平进行分组，采用Logistic回归模型分析血糖血压水平与动脉硬化的关系。结果共纳入1214例患者，其中动脉硬化异常（baPWV≥1700cm／s）有637人，占52．47％。相关性分析显示baPWV与HbAlc（rs=0．174，P=0．000）、SBP（rs=0．481，P=0．000）及DBP（rs=0．167，P=0．000）均呈正相关。Logistic回归分析显示，调整其他危险因素后，HbAlc和SBP每增加1个四分位数间距动脉硬化异常风险分别为1．41倍（95％CI：1．16～1．70）和3．71倍（95％CI：2．80～4．91）。结论糖尿病合并高血压患者baPWV与HbAlc及SBP显著相关，同时控制血糖和血压可能有利于降低动脉硬化异常发生风险。

英文摘要：

Objective To investigate the relationship between arterial stiffness and blood glucose or blood pressure in community pa- tients with diabetes mellitus and hypertension. Methods Diabetic patients with hypertension aged 40 or above were enrolled from rural communities of Beijing. Every patient completed a standardized questionnaire and underwent physical examinations, braehial - ankle pulse wave velocity （baPWV） measurements, blood tests. Patients were divided into groups according to the level of glycated hemoglobin （HbAle） , systolic blood pressure （SBP） and diastolic blood pressure （DBP）. Analyses were performed by using multiple logistic regres- sion model to explore the relationship between baPWV and blood glucose/blood pressure. Results Among 1214 patients enrolled, the detection rate of arterial stiffness （baPWV〉 1700cm/s） was 52.47%. Correlation analysis showed baPWV was positively associated with HbAle （r =0.174, P=0.000）, SBP （r =0.481, P=0.000） and DBP （r =0.167 P=0.000）. Aftermultivariable adjustment, an increase of one IQR （from 25th to the 75th percentile） in the HbA1 c and SBP was associated with greater risk of arterial stiffness [ HbA1 c （ an increase of 2% ） ： OR=1.41 （95% CI： 1.16-1.70）; SBP （an increase of 23mmHg）： OR=3.71 （95% CI： 2.80-4.91）]. Conclusion The blood glucose/blood pressure was associated with baPWV among diabetic patients with hypertension. Combined efforts to improve both blood pressure and glycemie control may help to reduce the risk of arterial stiffness.