中文摘要：

目的探讨加巴喷丁（GBP）应用于糖尿病神经痛（DPN）治疗的效果,分析其对血清TNF-α和IL-6水平的影响。方法选取DPN患者48例,根据是否服用GBP分为分为GBP组与DPN对照组各24例,并选取同时期无神经痛糖尿病患者24例为DM组,及同时期健康体检者24例为正常对照组,对GBP组及DPN组治疗前及治疗1、2、4周后视觉模拟评分进行对比,并对血清TNF-α和IL-6水平进行测定。结果与NC组对比,DM组、GBP组及DPN对照组患者的空腹血糖水平显著升高;治疗后,与DPN对照组对比,GBP组各时期的VAS评分均低于DPN对照组,且GBP组各时期VAS评分对比差异均有统计学意义（P〈0.05）;与NC组对比,GBP组、DPN对照组及DM组血清TNF-α、IL-6水平显著升高,其中GBP组、DPN对照组血清TNF-α、IL-6水平显著高于DM组,GBP组治疗后血清TNF-α、IL-6水平明显低于治疗前及同期DPN对照组,差异有统计学意义（P〈0.05）。结论加巴喷丁对糖尿病神经痛的疗效显著,并能降低血清TNF-α、IL-6水平,值得临床推广。

英文摘要：

Objective To investigate the effect of gabapentin in the treatment of diabetic neuropathic pain（DPN）,and analyze the influence on TNF-αand IL-6levels.Methods Forty-eight patients with DPN were divided into GBP group and DPN control group according to whether they were treated with GBP.Twenty-four DM patients without DPN were regarded as DM group while another twenty-three healthy patients were regarded as NC group.Visual analogue scales（VAS）of GBP and DPN groups were compared before treatment and 1,2weeks,4weeks after treatment.The TNF-αand IL-6levels were also compared in the same period.Results Compared with NC group,the fasting blood-glucose levels of DM group,GBP group and DPN control group were significantly higher;VAS score of DPN group were significantly lower than those in GBP group in the same period.TNF-αand IL-6levels of GBP group,DPN group and DM group were significantly higher than those in NC group.Furthermore,the TNF-αand IL-6levels of GBP group and DPN group were also significantly higher than those in DM group and TNF-αand IL-6levels of GBP group were increased after treatment（P〈0.05）.Conclusion Gabapentin applied to the treatment of diabetic neuropathic pain is effective,and can reduce the serum TNF-αand IL-6levels,so it is worthy of clinical application.