中文摘要：

目的探讨1型糖尿病（T1DM）患者中蛋白酪氨酸磷酸酶2B抗体（IA-2βA）的分布规律及阳性患者的临床特征。方法采用放射配体法检测401例T1DM患者、200例正常对照血清中IA-2βA、IA-2A和谷氨酸脱羧酶抗体（GADA）水平，并分析抗体阳性患者的临床特征。结果（1）T1DM组IA-2βA阳性率8．7％（35／401），显著高于正常对照组（1．0％，P〈0．05）；（2）35例IA-2βA阳性患者中，同时合并IA-2A阳性的患者16例，阳性重叠率45．7％。IA-2BA与IA-2A指数无相关性（r=0．021，P=0．780）；（3）T1DM患者中，IA-2A、IA-2βA阳性率在0～9岁组最高，二者阳性率显著高于10岁以上的T1DM患者（62．8％vs 19．7％，Χ^2=31．41，P〈0．001；20．0％vs 7．6％，Χ^2=6．11，P〈0．05）。而GADA阳性率在各年龄组中差异无统计学意义；（4）与单独IA-2A阳性患者比较。单独IA-2βA阳性患者年龄和起病年龄较大（IA-2A阳性患者平均年龄24．2岁，平均起病年龄21．6岁；IA-2βA阳性患者平均年龄35．5岁，平均起病年龄34．0岁，均P〈0．05）。结论IA-2βA在儿童T1DM患者中阳性率较高，且随年龄增长阳性率下降。IA-2βA是糖尿病患者自身免疫检测的一项实用指标。

英文摘要：

Objective To explore the prevalence and clinical features of protein tyrosine phosphatase-2β antibody （IA-2βA） in type 1 diabetes（T1DM）. Methods Four hundred and one T1DM patients and 200 healthy controls were screened for glutamic acid carboxylase antibody （ GADA）, islet cell antigen-2 （IA-2A）, IA-2βA by radioligand assay. The clinical features of the patients positive in different antibodies were analyzed. Results Thirty-five of the 401 T1DM patients were positive in IA-2βA with a positivity rate of 8.7%, significantly higher than that of the normal controls（ 1.0 % ,2/100, P 〈 0.05 ）. Out of the 35 cases with IA-2βA positivity, 16 （45.7%） were positive in IA-2A. Among the 401 T1DM patients, IA-2βA titer was not correlated with IA-2A titer （ r = 0.021, P = 0. 780）. The IA-2βA positive rate of the age group of 0 - 9 years was 62.8%, significantly higher than that of the age group 〉 10 years （ 19.7 %, Χ^2 = 31.41, P 〈 0.001 ） ;and the IA-2A positive rate of the age group of 0 - 9 years was 20.0 %, significantly higher than that of the age group 〉 10 years （7.6 % ,Χ^2 =6.11 ,P 〈0.05）. GADA was not significantly correlated with age. The age and onset age of the patients positive only in IA-2βA were 35.5 and 34.0 years respectively, both significantly higher than those of the patients positive only in IA-2A （24.2 and 21.6 years respectively, both P 〈 0.05）. Conclusion Higher in child-onset T1DM, the prevalence of IA-2βA positivity decreases with age. IA-2βA is a practical parameter for identifying autoimmune diabetes.