中文摘要：

背景发炎和凝结亲密地是二大多数的 cross-linked 防卫机制，如果并非所有有机体到损害。在期间心肺绕过(CPB ) ，这二过程被激活并且通过几条普通小径与对方一起交往，它可以导致随后的机关机能障碍。在现在的学习，我们假设了氮的氧化物，前列腺素 E1 (PGE1 ) ，和到全身的发行量的 aprotinin 的增加，在此把冬眠叫作血，将稀释 CPB 导致的发炎和凝结。三十条成年杂种狗同等地被划分成五个组，的方法 anesthetized 并且放了在低体温的 CPB (32 C ) 上。每个组分别地接受了下列处理：(1 ) 40 ppm 的吸入氮的氧化物；(2 ) 20 ng 的静脉内的注入 ?????  ???  ???? ￣ ???????? 倠 ???‵？？

英文摘要：

Background Inflammation and coagulation are two intimately cross-linked defense mechanisms of most, if not all organisms to injuries. During cardiopulmonary bypass （CPB）, these two processes are activated and interact with each other through several common pathways, which may result in subsequent organ dysfunction. In the present study, we hypothesized that the addition of nitric oxide, prostaglandin E1 （PGE1）, and aprotinin to the systemic circulation, hereby referred to as blood hibernation, would attenuate the inflammation and coagulation induced by CPB. Methods Thirty adult mongrel dogs were equally divided into five groups, anesthetized and placed on hypothermic CPB （32℃）. Each group received respectively the following treatments： （1） inhalation of 40 ppm nitric oxide; （2） intravenous infusion of 20 ng.kgl.min1 of PGE1; （3） 80 000 kallikrein inhibitor units （KIU）/kg of aprotinin; （4） the combination of all three agents （blood hibernation group）; and （5） no treatment （control group） during CPB. Activation of leukocyte, platelet, endothelial cell, and formation of thrombin were assessed after CPB. Results As compared with the other four groups, leukocyte counts were higher, while plasma elastase, interleukin-8, CD11b mRNA expression, myeloperoxidase activities and lung tissue leukocyte counts were lower in the blood hibernation group （P 〈0.05 versus other four groups after CPB）. Plasma prothrombin fragment （PTF）1＋2, and platelet activation factors were lower, while platelet counts were higher in the blood hibernation group （P 〈0.05 versus other four groups at 6 and 12 hours after CPB）. Electron microscopy showed endothelial pseudopods protrusion, with cell adherence in all four groups except the blood hibernation group where endothelial cells remained intact. Conclusion Blood hibernation, effected by the addition of nitric oxide, PGE1 and aprotinin to the circulating blood during extra-corporeal circulation, was observed to attenuate the inflamm