中文摘要：

目的：研究胰岛素（INS）、胰岛素样生长因子结合蛋白-7（IGFBP-7）及乙二醛酶Ⅰ（GLO1）在子宫内膜癌（EC）患者血清中的表达及其临床意义。方法：采用酶联免疫吸附（ELISA）法检测60例EC患者、60例子宫内膜不典型增生患者、60例子宫内膜息肉患者及60例健康妇女血清中INS、IGFBP-7及GLO1的表达水平,并分析3者的相关性及其与EC的关系。结果：EC组血清INS水平显著升高（817.96±90.08）,与子宫内膜不典型增生组、子宫内膜息肉组及正常子宫内膜组比较差异均有统计学意义（P〈0.05）;EC组血清IGFBP-7表达水平（24.77±3.19）显著高于其他3组（P〈0.05）;EC组GLO1表达水平（92.96±10.99）显著高于其他3组（P〈0.05）。INS与IGFBP-7及GLO1表达水平均呈正相关（r=0.970,P〈0.05;r=0.983,P〈0.05）;IGFBP-7与GLO1表达水平呈正相关（r=0.972,P〈0.05）。年龄及肥胖指数均是EC发病的危险因素（OR=1.218,P〈0.05;OR=1.103,P〈0.05）。结论：INS、IFFBP-7及GLO1升高是EC发生的相关危险因素。检测血清中IGFBP-7及GLO1水平,结合患者年龄及肥胖指数可用于评估EC的发生风险,从而有利于早期预防。

英文摘要：

Objective:To research the expressions of insulin (INS),insulin-like growth factor binding protein-7 (IGFBP-7),and glyoxalase Ⅰ (GLO1) in serum of endometrial cancer patients and the clinical significance.Methods:ELISA was used to detect the expression levels of INS,IGFBP-7,and GLO1 in serum specimens of 60 endometrial cancer patients,60 endometrial atypical hyperplasia patients,60 endometrial polyp patients,and 60 healthy women; the correlation among the three indexes and their relationships with endometrial cancer were analyzed.Results:Serum INS level in endometrial cancer group increased significantly (817.96 + 90.08),compared with endometrial atypical hyperplasia group,endometrial polyp group,aud normal endometrium group,there were statistically significant differences (P ＜ 0.05) ; serum IGFBP-7 expression level in endometrial cancer group was (24.77 ± 3.19),which was statistically significantly higher than those in the other three groups (P ＜ 0.05) ; serum GLO1 expression level in endometrial cancer group was (92.96± 10.99),which was statistically significantly higher than those in the other three groups (P ＜ 0.05).The expression levels of INS and IGFBP-7 were positively correlated with the expression level of GLO1,respectively (r =0.970,P ＜ 0.05 ; r =0.983,P ＜ 0.05) ; there was a positive correlation between IGFBP-7 expression level and GLO1 expression level (r =0.972,P ＜ 0.05).Age and obesity index were risk factors of endometrial cancer (OR =1.218,P ＜ 0.05; OR =1.103,P ＜ 0.05).Conclusion:High expressions of INS,IFFBP-7,and GLO1 are related risk factors of endometrial cancer.Detection of serum IGFBP-7 and GLO1 combined with age and obesity index can be used to evaluate the risk of endometrial cancer,which is conducive to early prevention.