中文摘要：

趋化因子CCL18通过招募炎症细胞参与机体的免疫和炎症过程,发挥免疫调控作用.在肿瘤患者血清及某些肿瘤组织中CCL18蛋白表达明显增加.然而CCL18在肿瘤中是发挥促癌作用还是抑癌作用尚存在争议.研究CCL18的作用及作用机制能够为肿瘤诊治提供新的靶向目标.

英文摘要：

Chemokine CCL18 plays significant roles in immune regulation by recruiting of inflammatory cells, which involves in immune and inflammatory processes. CCL18 protein is overexpressed in the serum of patients with cancer and some tumor tissues. However, it is still controversial that CCL18 plays the role of tumor promoter or tumor suppressor. Researches on the roles and mechanisms of CCL18 can provide new target for diagnosis and treatment of cancer.