中文摘要：

目的：观察舒胃汤对功能性消化不良（FD）大鼠胃肠动力、血清干细胞因子（SCF）及Cajal间质细胞（ICC）修复与再生的影响。方法：将72只大鼠随机分为对照组、模型组、舒胃汤低剂量组（舒低组）、舒胃汤中剂量组（舒中组）、舒胃汤高剂量组（舒高组）及莫沙比利组（西药组）,每组12只。舒低组、舒中组、舒高组分别给予舒胃汤0.767、1.534、3.068g/m L,莫沙必利组予莫沙必利1.37mg/kg。采用复合病因造模（慢性束缚应激＋过度疲劳＋饮食失节）,造成FD肝郁脾虚证大鼠模型。造模后第3天各组给予相应药液,对照组和模型组每日予以蒸馏水（10m L/kg）,均为每日1次,持续14d。第15天处死大鼠检测胃排空和小肠推进率,取血做血清SCF检测,取胃窦组织和小肠组织做荧光双染色观察ICC及神经纤维的形态。结果：模型组与对照组比较胃排空延迟,胃内残留率升高,小肠推进率下降,两组比较（P〈0.01）。舒高组、舒中组、莫沙必利组与模型组比较胃内残留率显著降低（P〈0.01）,小肠推进率显著升高（P〈0.01）。模型组与对照组比较,血清干细胞因子显著下降（P〈0.01）,舒高组、舒中组和莫沙必利组与模型组比较,血清干细胞因子显著上升（P〈0.01）,舒低组与模型组比较有上升（P〈0.05）。模型组与对照组比较,ICC超微结构损伤明显,胆碱能神经-ICC-SMC网络结构紊乱,ICC和神经纤维数目减少（P〈0.01）,荧光强度显著减弱（P〈0.01）。舒高组、舒中组和莫沙必利组与模型组比较,ICC超微结构较为正常完整,胆碱能神经-ICC-SMC网络基本完整,ICC和神经纤维数目显著增多（P〈0.01）,荧光强度显著加强（P〈0.01）。结论：舒胃汤可能通过提高SCF的表达,增强ICC的增殖,分化及表型的维持,从而促进ICC形态的修复和功能的恢复以及ICC的再生,保持胆碱能神经-ICC-SMC网络结构的完整,提高神?

英文摘要：

Objective： To observe the influence of Shuwei Decoction on gastrointestinal motility, stem cell factor in the serum and the repair and regeneration of Cajal interstitial cell in rats with functional dyspepsia. Methods： 72 rats were randomly divided into control group, model group, high dosage of Shuwei Decoction group （HSG）, middle dosage of Shuwei Decoction group （MSG）, low dosage of Shuwei Decoction group （LSG） and mosapride group with 12 rats in each group. Rats in LSG, MSG and HSG received gavage administration with Shuwei decoction with dosage of 0.767g/mL, 1.534g/mL and 3.068g/mL, and rats in mosapride group received gavage administration with mosapride with dosage of 1.37mg/kg. Syndrome of stagnation of liver qi and spleen deficiency rat models with functional dyspepsia established by using compound cause method （chronic restraint stress ＋ over fatigue ＋ improper diet）. On the 3rd day after rat model establishing, rats in each group were treated with corresponding drugs, and rats in control group and model group received gavage administration with distilled water （10mL/kg） daily, and lasted for 14 days. All the rats were sacrificed on the 15th day, and gastric emptying and small intestinal propulsion rates were detected. Stem cell factor in serum and ICC and shape of nerve fibers in gastric antrum and small intestine tissue were tested. Results： Compared with control group, gastric emptying of rats in model group was delayed, gastric residual rate was increased, and propelling rate of small intestine was decreased significantly （P〈0.01）, Compared with model group, the gastric residual rate of rats in HSG, MSG and mosapride group was decreased significantly, and propelling rate of small intestine was increased significantly （P〈0.05）. In comparison of the levels of stem cell factors in serum, HSG, MSG, LSG and mosapride group were higher than model group （P〈0.01, P〈0.05）. Compared with control group, in rats of model group, the ultra microstructure of ICC dam