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CD133和CD44在骨肉瘤中的表达及其临床意义
  • ISSN号:1000-8578
  • 期刊名称:肿瘤防治研究
  • 时间:2012
  • 页码:1328-1332
  • 分类:R738.1[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]上海交通大学附属第六人民医院肿瘤内科,上海200233, [2]上海交通大学附属第六人民医院病理科,上海200233
  • 相关基金:国家自然科学基金资助项目(81001191); 上海市科学技术委员会资助课题(10PJ1408300)
  • 相关项目:CD133阳性骨肉瘤细胞亚克隆在骨肉瘤肺转移中的作用及机制研究
中文摘要:

目的探讨CD133和CD44在骨肉瘤中的表达情况及其与骨肉瘤患者预后的关系。方法应用免疫组织化学方法检测CD133和CD44在79例骨肉瘤患者石蜡切片标本中的表达情况,应用卡方检验比较CD133、CD44表达与患者临床病理资料的相互关系,Kaplan-Meier法计算患者生存率,Log rank检验比较CD133、CD44阴性低表达组与高表达组患者之间的生存差异,并以性别、年龄、肿瘤部位、肿瘤大小、Ennecking分期、CD133和CD44表达水平、局部复发及肺转移为变量指标,应用Cox回归模型进行多因素分析,研究这些因素与骨肉瘤患者生存率之间的关系。结果 CD133和CD44的表达水平与患者性别、年龄、肿瘤部位、肿瘤大小、Ennecking分期及局部复发无关,发生肺转移的骨肉瘤患者其CD133和CD44的表达明显高于未发生转移的骨肉瘤患者,差异有统计学意义(P值分别为0.00014和0.0008)。经单因素生存分析表明,影响骨肉瘤患者预后的因素有:肿瘤大小,局部复发,肺转移,CD44和CD133表达水平。多因素分析显示CD133和CD44表达水平及肿瘤大小是影响患者预后的独立影响因素。结论 CD133和CD44表达水平与骨肉瘤肺转移密切相关,检测CD133和CD44的表达可以作为骨肉瘤患者肺转移及预后预测的指标。

英文摘要:

Objective To investigate the expressions of CD133 and CD44 in osteosarcoma tissue and their relationship with the prognosis of osteosarcoma.Methods Expressions of CD133 and CD44 were examined by immuno-histochemical MaxVision method in 79 specimens of human osteosarcoma tissues.The relationship between expression of CD133/CD44 and clinicopathological parameters was calculated by Chi-square test.Kaplan-Meier method was used to calculate the overall survival rate.The factors of gender,age,tumor-size,tumor location,Ennecking stage,local recurrence and lung metastasis were included in univariate analysis.The univariate analysis was used to determine the prognostic factors related with survival rate by Log rank test.The COX proportional-hazard regression model was used to analyze the correlation between the prognostic factor and survival.Results No correlations were found between expression of CD133/CD44 and clinicopathological parameters including gender,age,tumor location,tumor size,Ennecking stage and local recurrence,but occurrence of pulmonary metastasis was significantly associated with the expression levels of CD133/CD44(P value was 0.00014 and 0.0008,respectively).Univariate survival analysis showed that the significant prognostic factors were tumor size,local recurrence,lung metastasis,expression levels of CD133 and CD44.Multivariate analysis showed that CD133 and CD44 expression and tumor size were independent prognostic factors of patients with osteosarcoma.Conclusion The positive expressions of CD133 and CD44 closely correlate with the lung metastasis of osteosarcoma,detection of CD133 and CD44 may be used as an indicator for lung metastasis and prognosis of osteosarcoma.

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期刊信息
  • 《肿瘤防治研究》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国卫生部
  • 主办单位:湖北省卫生厅 中国抗癌协会 湖北省肿瘤医院
  • 主编:魏少忠
  • 地址:武昌卓刀泉南路116号
  • 邮编:430079
  • 邮箱:zlfzyj@263.net.cn
  • 电话:027-87670126
  • 国际标准刊号:ISSN:1000-8578
  • 国内统一刊号:ISSN:42-1241/R
  • 邮发代号:38-70
  • 获奖情况:
  • 中国学术期刊综合评价数据库来源期刊,中国科学引文数据库来源期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:17449