中文摘要：

运动诱导骨骼肌表达过氧化物酶体增殖物激活受体γ辅助激活因子α（peroxisome proliferator-activated receptor γ coactivator-1α，PGC-1α），PGC-1α通过多条途径参与调节骨骼肌的运动适应性。最新的研究发现PGC-1α在骨骼肌中可促进Ⅲ型纤连蛋白结构域5（fibronectin type Ⅲ domain-containing5，FNDC5）的表达，后者被转变为一种新的激素-Irisin。Irisin可使白色脂肪细胞转变为棕色脂肪细胞，因此PGC-1α和Irisin将成为肥胖症防治研究的新靶点。

英文摘要：

Exercise can induce the expression of PGC-1α in skeletal muscle. And PGC-1 can regulate skeletal muscle＇s adaptation to exercise through multiple signaling pathways. Moreover, recent research shows that PGC-1α can stimulate an increase in expression of FNDC5 （fibronectin type Ⅲ domain-containing 5）, which is cleaved and secreted as a newly identified hormone, Irisin. Irisin acts on white adipose cells to stimulate UCP1 （mitochondrial brown fat uncoupling protein 1） expression and a broad program of brown-fat-like development. PGC-1α and Irisin could be potential therapeutic target and medicine for the prevention and treatment of obesity.