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Synthesis of Hydroxyapatite Nanorods under Mild Conditions and Their Drug Release Properties

ISSN号：1001-604X
期刊名称：《中国化学：英文版》
时间：0
分类：TQ174.759[化学工程—陶瓷工业;化学工程—硅酸盐工业] TB383[一般工业技术—材料科学与工程]
作者机构：[1]Department of Chemistry, School of Science, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China
相关基金：This project is financially supported by the National Natural Science Foundation of China （No. 51402073）, the China Postdoctoral Science Foundation （No. 2013M531030） and ＂the Fundamental Research Funds for the Central Universities＂（Nos. HIT. NSRIF. 2012064, HIT. NSRIF. 2011018）.

作者： Deyan Kong Xinli Xiao Xueying Qiu Wenbo Zhang Yulin Yang[1]

关键词：羟基磷灰石, 纳米棒, 释药性能, 温和条件, 合成, Ostwald熟化, 表面活性剂, 晶体表面, synthesis design, nanoparticles, drug delivery, crystal growth

中文摘要：

Hydroxyapatite (幸运) nanorods 在各种各样的地里拥有广阔潜在的应用程序，并且这里，有高方面比率的幸运 nanorods 在气压下面在 60 °C 经由方便二阶段的降水水解作用进程被综合。在降水舞台的 CaHPO ₄ 的先锋很好作为表面活化剂与 CTAB 作为瘤多的形态学被使结晶，当 CaHPO ₄ 被溶解， CTA ⁺ 在水解作用阶段期间稳定了幸运原子核时。哦在 Ca ²⁺ 和 PO ₄³⁺ 反应了与的地方， ⁻ 离子被吸收到活跃水晶表面上哦让原子核长成更大的晶体的 ⁻ ，和高度水晶的幸运 nanorods 被 Ostwald 成熟获得。幸运晶体上的 IBU 的装载的药能百分之百在 24 h 被释放。PVP 修改了幸运 nanorods 罐头增加比纯幸运 nanorods 快的装载药的能力和版本药。结果显示与合适的表面活化剂修改的幸运 nanorods 具有在药交货系统的大使用。

英文摘要：

Hydroxyapatite （HAp） nanorods possess vast potential applications in various fields, and here HAp nanorods with high aspect ratio were synthesized via a convenient two-stage precipitation-hydrolysis process at 60℃ under atmospheric pressure. The precursor of CaHPO4 at precipitation stage is well crystallized as nubby morphology with CTAB as surfactant, while CaHPO4 was dissolved and CTA＋ stabilized the HAp nuclei during the hydrolysis stage. OH- ions were absorbed onto the active crystal surface, where Ca2＋ and PO4 3- reacted with OH- to make the nuclei grow into larger crystals, and highly crystalline HAp nanorods were obtained by Ostwald ripening. The loaded drug of IBU on the HAp crystals can be 100% released in 24 h. PVP modified HAp nanorods can increase the drug-loading capacity and release drug faster than pure HAp nanorods. The results indicate that HAp nanorods modified with suitable surfactants are of great use in drug delivery system.

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