目的:检测FGF2在横纹肌肉瘤组织中的表达并初步探讨其临床病理学意义。方法:应用免疫组织化学法检测FGF2蛋白在45例横纹肌肉瘤组织中的表达。结果:45例横纹肌肉瘤组织中23例FGF2阳性表达,阳性率为51.1%,FGF2蛋白表达水平在不同性别、年龄、预后、组织学类型、肿瘤大小和临床分期间差异无显著性(P〉0.05)。结论:FGF2与横纹肌肉瘤的发生发展存在一定相关性。
Objective: To investigate the expression of FGF2 in rhabdomyosarcoma and to discuss its clinical patho- logical significance in RMS preliminarily. Methods:Immunohistochemical staining was adopted to detect the expression of FGF2 protein in 45 cases of RMS. Results: The positive expression of FGF2 were 51. 1% ( 23/45 ) , The differences of FGF2 protein expression between the sex,age ,survive ,histology and clinical stage group are of no statistic significance( P 〉 0.05 ). Conclusion: FGF2 play a role during the occurrence and development of RMS.