中文摘要：

反复自然流产（RSA）的发病率约为0．5％～2．0％，其病因十分复杂，关于提供胚胎半数基因的男方因素，目前的研究主要集中在体细胞和生殖细胞基因两大方面。体细胞染色体异常、精子染色体变异、精子质量缺陷、基因突变、高龄、感染以及其他任何可以影响胎盘的父系基因异常均可导致RSA的发生。本文就上述可能导致RSA的男方因素的研究进展进行综述。

英文摘要：

Repeated spontaneous abortion （RSA）, with very complicated pathogenesis, has an incidence of about 0.5% - 2.0%. As for the paternal part which provides half of the genes for the embryo, current studies mainly focus on the genes of somatic cells or germ cells. Chromosome abnormality of somatic cells, chromosome disorder of sperm, defects in sperm quality, genetic mutation, senility, infection and any other paternal gene abnormalities that affect the embryo would induce RSA. This paper presents an update on the above mentioned paternal factors which might result in RSA.