中文摘要：

目的探讨口服阿托伐他汀用于全子宫切除术术后镇痛的效果。方法择期行腹式全子宫切除术患者90例随机均分为阿托伐他汀组（A组）和对照组（C组）。A组术前12h口服阿托伐他汀80mg，麻醉前即刻、术后12h和24h分别口服阿托伐他汀20mgl对照组口服安慰剂。记录术后不同时间点安静状态和90度翻身活动时的VAS疼痛评分、镇痛泵有效按压次数及不良反应。计算术后曲马多累积使用量。分别于麻醉前即刻、术后24h测定血清超敏C反应蛋白（hscRP）和IL-6水平。结果与C组相比，A组术后各时间点安静状态及90度翻身活动时的VAS评分、镇痛泵按压有效次数、曲马多累积使用量、术后恶心呕吐及出汗发生率均减少，术后24h时的hsCRP和IL-6水平均降低（P〈0．05）。结论阿托伐他汀能增强曲马多术后静脉镇痛的效果，且不良反应发生率低；其镇痛作用可能与抑制炎症介质释放有关。

英文摘要：

Objective To investigate the clinical efficacy of oral atorvastatin on postoperative analgesia in the patients undergoing total hysterectomy. Methods Ninety patients undergoing total abdominal hysterectomy were equally randomized into two groups. Group A was given oral atorvastatin 80 mg at 12 hours before surgery and 20 mg immediately before anesthesia, at 12 and 24 hours after surgery. Group C was given placebo pills at the same time pionts. At different time points after surgery,VAS pain score at rest and 90 degrees turn over and PCA effective pressing number were recorded, the total tramadol consumption in 24 and 48 hours after surgery was calculated and the adverse responses were observed. Serum levels of high sensitivity C-reactive protein（hsCRP） and interleukin-6（IL-6） were measured immediately before anesthesia and at 24 hours after, surgery. Results Compared with group C, the VAS scores, PCA effective pressing number, tramadol consumption,incidence rate of adverse effects, and serum levels of IL-6 and hsCRP at 24 hours after surgery were all decreased in group A （P〈0. 05）. Conclusion Oral atorvastatin can enhance the efficacy of postoperative intravenous analgesia with tramadol, which may be related to its suppressing effect on the inflammatory mediators.