中文摘要：

目的：探讨瑞舒伐他汀对脑缺血再灌注损伤大鼠脑组织中选择素E（E-selectin）和选择素L（L—selee．tin）表达的影响。方法：SD大鼠24只随机分为假手术组（sham）、模型组（model）和治疗组（test）。线栓法制作大鼠大脑中动脉脑缺血再灌注模型，于缺血2h再灌注24h后断头取脑，免疫组织化学法、RT—PCR法和WesternBlot检测脑组织中E．选择素和L-选择素的表达量，结果进行统计学分析。结果：大鼠脑缺血再灌注损伤后，模型组选择素E和选择素表达明显高于假手术组（P〈0．01）；与模型组相比，治疗组选择素E和选择素表达明显下调（P〈0．05）。结论：瑞舒伐他汀可能通过下调选择素E和选择素表达而对大鼠脑缺血再灌注损伤发挥保护作用。

英文摘要：

Objective： To explore expression of E-selectin and L-selectin affected by rosuvastatin in rats with the cere- bral ischemia-reperfusion. Methods： Rats were randomly assigned into three groups： sham operation group （sham group） , cerebral ischemia-reperfusion group （model group） and E-selectin and L-selectin group （test group）. The mid- dle cerebral artery occlusion reperfusion model was made by the suture method （ ischemia for 2 hours, and reperfusion for 24 hours）. The level of E-selectin and L-selectin expression was measured by immunohistochemistry, RT-PCR and West- ern Blot. Results： After eerebral ischemia reperfusion injuryin rats, compared with sham group, the expression of E-se- lectin and L-selectin were increased significantly in the model group （ P 〈 0.01 ）. Compared with model group, the expres- sion of E-selectin and L-selectin were decreased significantly in the test group （ P 〈 0.05 ）. Conclusion： Rosuvastatin can suppress the expression of E-selectin and L-selectin in cerebral isehemia-reperfusion.