位置：成果数据库 > 期刊 > 期刊详情页
Enantioselective Synthesis of Glutarimide Alkaloids Cordiarimides A, B, Crotonimides A, B, and Julocrotine
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：O621.34[理学—有机化学;理学—化学] O629.3[理学—有机化学;理学—化学]
  • 作者机构：[1]Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China
  • 相关基金：Project supported by the National Natural Science Foundation of China （No. 20832005） and the National Basic Research Program （973 Program） of China （No. 2010CB833200）.
作者： 滕波[1], 郑剑峰[1], 黄慧英[1], 黄培强[1]
关键词： 不对称合成, 生物碱, 不对称催化加氢, 非对映选择性, 谷氨酰胺, 手性中心, 催化系统, BOC, glutarimides, alkaloids, asymmetric hydrogenation, diastereoselectivity, enantiostetive synthesis
中文摘要：

五 glutarimide 碱 cordiarimide A (5 ) ， cordiarimide B (6 ) ， crotonimide A (3 ) ， crotonimide B (4 ) ，和 julocrotine (2 ) 被综合了从 Boc-L-glutamine (7 ) 开始。cordiarimides B (6 ) 的 benzylic 白酒 chiral 中心被催化不对称的加氢用周的催化系统 Pd (CF3CO2 )2/ 在 6:1 diastereoselectivity 建立了(R， R )-Me-DuPhos。

英文摘要：

Five glutarimide alkaloids cordiarimide A （5）, cordiarimide B （6）, crotonimide A （3）, crotonimide B （4）, and julocrotine （2） have been synthesized starting from Boc-L-glutamine （7）. The benzylic alcohol chiral centre of cordiarimides B （6） has been established in 6 ： 1 diastereoselectivity by catalytic asymmetric hydrogenation using Zhou＇s catalytic system Pd（CF3CO2）2/（R,R）-Me-DuPhos.

同期刊论文项目
重要生理活性天然产物的结构多样性合成研究
期刊论文 111 获奖 1 著作 2
　具有重要生物活性的天然产物的化学合成
期刊论文 26
同项目期刊论文
Reductive Hydroxyalkylation/ Alkylation of Amines with Lactones/ Esters
Asymmetric Synthesis of Both Enantiomers of Disparlure
Generation and alpha-hydroxyalkylation of a novel 3-piperidinol N-alpha-carbanion intermediate
Asymmetric Total Synthesis of (-)-Awajanomycin
Versatile One-Pot Reductive Alkylation of Lactams/Amides via Amide Activation: Application to the Co
Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobi
A Flexible Approach to Protected (4S,5S)-5-Alkyl-1-benzyl-4-benzyloxy-2-pyrrolidinones
Asymmetric syntheses of (8R,8aS)- and (8R,8aR)-8-hydroxy-5-indolizidinones: Two promising oxygenated
Versatile and Direct Transformation of Secondary Amides into Ketones via Organocerium Reagents-Based
Enantioselective Total Synthesis of (-)-Stenine
Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents
A Flexible Asymmetric Approach to Methyl 5-Alkyltetramates and Its Application in the Synthesis of C
SmI2-Mediated Radical Cross-Couplings of alpha-Hydroxylated Aza-hemiacetals and N,S-Acetals with alp
Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols
Enantioselective Synthesis of Glutarimide Alkaloids Cordiarimides A, B, Crotonimides A, B, and Juloc
Studies towards the Total Asymmetric Synthesis of the Pentacyclic Indole Alkaloid Arboflorine: Asymm
Amide Activation by Tf2O: Reduction of Amides to Amines by NaBH4 under Mild Conditions
A Flexible Approach to Azasugars: Asymmetric Total Syntheses of (+)-Castanospermine, (+)-7-Deoxy-6-e
Asymmetric Synthesis of the Cytotoxic Marine Natural Product (+)-Awajanomycin and Its C-11 Epimer
A Concise, Protection-Free and Divergent Approach for the Enantioselective Syntheses of Two Pheromon
Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents
A flexible approach for the asymmetric syntheses of hyacinthacines A(2), A(3) and structural confirm
Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Re
Studies towards an Enantioselective Total Synthesis of Sarain A: A Concise Asymmetric Construction o
Concise synthesis of two advanced intermediates for the asymmetric synthesis of polyhydroxylated ind
N-Benzyloxymalimide for an easy access to 5-alkyl-3-pyrrolin-2-ones: asymmetric synthesis of the mix
Highly diastereoselective addition of alkynylmagnesium chlorides to N-tert-butanesulfinyl aldimines:
(8R,8aS)-及(8R,8aR)-8-羟基-5-吲哚里西啶酮的不对称合成:两个有用的羟基吲哚里西啶合成砌块
A study on the racemization step in the synthesis of pyrrolidinols via cyclic alpha-hydrovimides
SmI2-Mediated Intermolecular Coupling of Lactam N-?-Radicals with Activated Alkenes: Asymmetric Synt
Practical, environment-benign and atom economic KOAc-catalysed deprotection of aryl TIPS ethers unde
A concise and fully selective synthesis of the ant venom alkaloid (3S,5R,8S,9S)-3-butyl-5-propyl-8-h
Enantioselective Synthesis of the R-Enantiomer of the Feeding Deterrent (S)-Ypaoamide
New and Concise Approach to (R)-alpha-Lipoic Acid
3-羟基哌啶氮α-碳负离子的形成及α-羟烷化反应
A Flexible Approach to Methyl (5S)-5-Alkyltetramate Derivatives
A new approach to 3-hydroxyprolinol derivatives by samarium diiodide-mediated reductive coupling of
An enantioselective synthesis of (+)-azimic acid
A Flexible Common Approach to alpha-Substituted Serines and Alanines: Diastereoconvergent Syntheses
Asymmetric Syntheses and Wnt Signal Inhibitory Activity of Melleumin A and Four Analogues of Melleum
Oxidative Carbon-Carbon Bond Formation in the Synthesis of Bioactive Spiro beta-Lactams
A versatile approach to cis-5-substituted 4-hydroxy-2-pyrrolidinones: asymmetric synthesis of angiog
LiOAc-catalyzed chemoselective deprotection of aryl silyl ethers under mild conditions
Total Synthesis of Emericellamide A: A Secondary Metabolite of Marine Cyclic Depsipeptide with Antim
Asymmetric syntheses of 6-deoxyfagomin, D-deoxyrhamnojirimycin, and D-rhamnono-1,5-lactam
Antityrosinase and Antimicrobial Activities of trans-Cinnamaldehyde Thiosemicarbazone
One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds
FACILE SYNTHESES OF THREE AHP-TYPE BUILDING BLOCKS WITH COMPLEMENTARY REACTIVITIES
BF(3)center dot Et(2)O catalyzed diastereoselective nucleophilic reactions of 3-silyloxypiperidine N
A Formal Enantioselective Total Synthesis of FR901483
Samarium diiodide-mediated reductive couplings of chiral nitrones with aldehydes/ketones and acyl ch
The first enantioselective synthesis of cytotoxic marine natural product palau'imide and assignment
Direct B-Alkyl Suzuki-Miyaura Cross-Coupling of Trialkylboranes with Aryl Bromides in the Presence o
A new method for the construction of the hydroxylated tropane skeleton: enantioselective synthesis o
Concise asymmetric synthesis of (-)-deoxoprosophylline
仲酰胺经酰胺活化直接合成酮的普适性方法
Copper-Catalyzed Arylation of o-Bromoanilides: Highly Flexible Synthesis of Hexahydropyrroloindole A
Unexpected highly diastereoconvergent Grignard additions to D-xylofuranose-derived t-butanesulfinyl
A Short and Flexible Synthetic Approach to the Naturally Occurring Racemic Neoclausenamide and Its A
Enantioselective Syntheses of Rigidiusculamides A and B: Revision of the Relative Stereochemistry of
Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reducti
A flexible approach to construct three contiguous chiral centers of sphingolipids, and asymmetric sy
Towards Reaction Control: cis-Diastereoselective Reductive Dehydroxylation of 5-Alkyl-4-benzyloxy-5-
Flexible synthesis of montanine-like alkaloids: revisiting the structure of montabuphine
A concise and divergent approach to radicamine B and hyacinthacine A(3) based on a step-economic tra
An unexpected high erythro-selection in the Grignard reaction with an N,O-acetal: a concise asymmetr
One-pot reductive coupling of N-acylcarbamates with activated alkenes: Application to the asymmetric
Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: Novel tyrosinase inhibito
缩氨基硫脲化合物的合成及对菜青虫酚氧化酶抑制作用研究
一个多用途吡咯烷类氮杂糖中间体的不对称合成
A Short and Flexible Synthetic Approach to the Naturally Occurring Racemic Neoclausenamide and Its Analogs
Towards Stereochemical Control＂ Two Approaches for the Highly anti.Diastereoselective Construction of the Spirolactone Moieties of Some Stemona Alkaloids
Asymmetric Synthesis of Both Enantiomers of Disparlure
氧化偶联策略在复杂吲哚生物碱全合成中的应用
Renieramycin类生物碱的合成研究进展
On the Absolute Configuration of Schweinfurthinol
仲酰胺经酰胺活化直接合成酮的普适性方法
高分子负载催化剂的设计、合成及其在有机合成反应中的应用
Recent progress in the research on lamellarins and related pyrrole-derived alkaloids from marine organisms
铜催化的4-碘色氨酸衍生物的N-芳基化反应及其在Indolactam V全合成中的应用
海洋二聚吡咯-咪唑类生物碱
Studies Directed toward Synthesis of the Structure Proposed for Stereocalpin A
Synthesis of （-）-Harzialactone A from a Readily Accessible Epoxy Chiral Building Block
Synthesis of an Antitumoral Diarylheptanoid Containing 1,3-Diol Functionality
A Clear-Cut Synthesis of Arteannuin O
Absolute Configuration of the Phenylpropanoid Isolated from Peperomia tetraphylla
大环内酯类免疫抑制剂他克莫司的生物合成机制研究进展
3,4-桥环吲哚类生物碱的合成研究进展
A Short and Flexible Synthetic Approach to the Naturally Occurring Racemic Neoclausenamide and Its Analogs
乌药烷型倍半萜及其二聚体的全合成研究进展
Stereospecific Synthesis of Drospirenone
A Formal Synthesis of Iridoid 9-Deoxygelsemide
Towards Stereochemical Control＂ Two Approaches for the Highly anti.Diastereoselective Construction of the Spirolactone Moieties of Some Stemona Alkaloids
Biomimetic Cationic Cyclization toward ent-Kaurene-type Diterpenoids
分子内氧化偶联反应在合成复杂吲哚生物碱骨架中的应用
One-pot Synthesis of Aromatic Fused 2,3-Dihydroindanone by Tandem Pauson-Khand/Michael/Henry Reaction
具有反式六氢茚满结构的萜类化合物的合成研究进展
期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175