中文摘要：

目的：通过检测哮喘患者心率变异性（heart rate variability，HRV）水平，探讨HRV是否可以做为一种预警哮喘发作及病情变化的客观指标。方法检测200例慢性持续期或临床缓解期哮喘患者HRV，并动态观察其后1个月病情变化，分析HRV变化与哮喘患者急性发作的相关性。结果哮喘急性发作患者与哮喘稳定期患者HRV比较，反映迷走神经张力的高频（high frequency，HF）和pNN50增高，差异有显著性（P〈0.05）；而主要反映交感神经张力的低频（low frequency，LF）和SDANN下降，差异有显著性（P〈0.01，P〈0.05）；PEF值/预计值（%）下降，差异有显著性（P〈0.05）。结论支气管哮喘急性发作与自主神经功能紊乱有关，HRV能作为一种预警支气管哮喘急性发作的客观指标，其中以LF为主要参考，并且通过连续观察患者PEF值，可以发现病情恶化的早期征象。

英文摘要：

Objective By detecting the level of heart rate variability in patients with asthma,Discuss whether HRV can be used an objective indicator as early warning of asthma attack and disease variety. Methods Through test 200 cases asthma Pa-tients of chronic duration or clinical remission with HRV,And dynamic observation followed by 1 months the condition changes,to analyze the correlation between HRVchanges and asthma patients with acute exacerbation. Results Compared to asthma patients of Acute attack and in stable stage HRV,High Frequency （HF） that Reflect vagal tone and pNN50 increased,the difference was significant（P〈0.05）;The low frequency （LF） that reflect sympathetic nerve tension and SDANN decreased,the difference was signif-icant （P〈0.01,P〈0.05）;PEF/predicted（%） decreased,the difference was significant（P〈0.05）. Conclusion Acute attack of bronchial asthma is associated with dysfunction of the autonomic nervous system,HRV can be used as an objective index of warn bronchial asthma acute attack,which takes LF as the main reference,and through continuous observation of patients with PEF value,can be found early signs of deterioration.