中文摘要：

DNA甲基化是肿瘤发生的一种重要表观遗传学变化,并已被证实与结直肠癌的发生发展密切相关。本文介绍DNA甲基化的形成机制以及重要性,结合近期国内外DNA甲基化异常与结直肠癌关系的研究进展,总结食品生物活性物质如何通过调控甲基基团代谢或DNA甲基化转移酶活性来调节DNA甲基化,从而影响结直肠癌发生发展的机制。

英文摘要：

Aberrant DNA methylation,as a vital epigenetic change,has been shown to be closely associated with the occurrence and development of colorectal cancer.This paper reviews recent progress in the mechanism of arrant DNA methylation and its importance as well as the relationship between arrant DNA methylation and colorectal cancer at home and abroad.Besides,the regulatory mechanisms of food-derived bioactive substances on DNA methylation by controlling the metabolism of methyl groups and the activity of DNA methyltransferases so as to influence the occurrence and development of colorectal cancer are herein summarized.