The level of present understanding of earthquake prediction of seismologists at home and abroad is very different. This is because China has opened up a special path of earthquake prediction research that has not been explored by other countries, with its own advantages and potentialities.Therefore, we considered that it is the most practical way to use the advantages and potentialities for raising the earthquake prediction level. For this purpose, we have developed a set of intelligent decision support system for earthquake prediction, with the analysis of cluster anomalies process at the core. The facts show that it can obviously raise the level of synthetic earthquake prediction.