中文摘要：

探讨白细胞介素17（IL-17）、基质金属蛋白酶9（MMP-9）在非小细胞肺癌（NSCLC）组织中的表达及其与pTNM分期的相互关系。方法：应用免疫组织化学法检测102例癌组织和癌旁组织中IL-17、MMP-9的表达，并对其与pTNM分期的关系进行统计分析。结果：IL-17、MMP-9在NSCLC癌组织阳性表达率分别为73.53%（75/102）和 60.78%（62/102）,癌旁组织中分别为71.57%（73/102）、7.84%（8/102）；二者在不同pTNM分期癌组织中表达差异均有统计学意义（P＜0.05），癌组织中IL-17与MMP-9的表达有相关性 （P＜0.05），在癌旁组织中的表达无相关性（P＞0.05）。结论：IL-17和MMP-9在NSCLC中表达上调,两者在癌组织的表达呈正相关，两者可能共同参与了NSCLC浸润和转移,需要进一步明确IL-17、MMP-9在肿瘤微环境中的调控机制。

英文摘要：

[Abstract] Objective： To investigate the helper T cells 17 （TH17） Cytokine activity IL17, matrix metalloproteinase -9 （MMP-9） in non-small cell lung cancer （NSCLC） tissues and expression relationship for pTNM staging. Methods： Immunohistochemistry was used to detect 102 cases of cancer and adjacent tissues in IL17 and MMP9 expression of non-small cell lung carcinoma. χ2 test was used to compare the ratio of its relationship with the pTNM stage analysis. Results： IL-17, MMP-9 expression rates in NSCLC cancer were 73.53%（75/102）, 60.78%（62/102） respectively, different TNM staging of IL-17, MMP-9 expression were statistically significant （P〈0.05） respectively, The expression of IL-17 and MMP-9 in NSCLC tumor tissue were related to differences （P〈0.05）,and adjacent tissues were not related to differences （P〉0.05）. Conclusion： IL-17, MMP-9 in non-small cell lung cancer tissues increased, both may be involved in invasion and metastasis of non-small cell lung cancer, IL-17 and MMP-9 in NSCLC tumor tissue were correlated and adjacent tissues expression were not correlated, further defined the IL-17, MMP-9 in the tumor microenvironment in the regulation mechanism.