中文摘要：

目的研究沐舒坦联合异丙托溴铵雾化吸入治疗重型颅脑创伤后肺部感染的效果。方法将81例重型颅脑创伤后肺部感染患者按随机原则分为对照组（40例）和沐舒坦联合异丙托溴铵组（41例）。在常规治疗基础上，对照组给予沐舒坦雾化吸入治疗，沐舒坦联合异丙托溴钱组给予沐舒坦联合异丙托溴铵雾化吸入治疗。观察并比较两组患者治疗前及治疗10天后体温、白细胞计数、动脉血氧分压、动脉血气分析氧合指数变化；比较两组患者治疗10d时的感染控制率以及感染控制平均时间。结果两组患者治疗10d后与本组治疗前相比，体温均明显下降，白细胞计数均明显降低、动脉血氧分压和动脉血气分析氧合指数均明显升高，差异具有统计学意义（均P〈0．01）；沐舒坦联合异丙托溴铵组患者治疗10d后与对照组治疗10d后相比，体温下降更快（36．86±0．72比37．32±0．81），白细胞计数更低（7．63±2．34比9．08±2．52），动脉血氧分压更高（90．74±9．07比84．88±8．65），动脉血气分析氧合指数更高（308．62±31．67比281．19±33．06），差异均有统计学意义。沐舒坦联合异丙托溴铵组治疗10d时的感染控制率明显高于对照组（82．9％比62．5％）；沐舒坦联合异丙托溴铵组的感染控制平均时间明显短于对照组（6．3±2．4比12．8±4．5）。结论沐舒坦联合异丙托溴铵雾化吸入对于患者重型颅脑创伤后肺部感染的治疗效果明显优于单独使用沐舒坦治疗，有临床推广价值。

英文摘要：

Objective To explore the effect of Mucosolvan joint Ipratropium bromide atomization inhalation in the treatment for patients with pulmonary infection after severe traumatic brain injury. Methods 81 patients with pulmonary infection after sTBI were randomly divided into control group （n=40） and Mucosolvan joint Ipratropium group （n=41）. Both groups were given conventional treatment. In the control group, Mucosolvan atomization inhalation was given while Mucosolvan joint Ipratropium bromide atomization inhalation was given to the Mucosolvan joint Ipratropium group. The changes of patients＇ body temperature, white blood cell count, arterial oxygenation and Oxygenation index in both groups were compared after 10 days＇ treatment. The rate of infection control and the mean time of infection control in both groups were compared after 10 days＇ treatment. Results In both groups, the patients＇ body temperature, white blood cell count, arterial oxygenation and Oxygenation index were significantly improved after 10 days＇ treatment （P〈 0.01）. Comparing with the control group, the Mucosolvan joint Ipratropium group, its body＇ s temperature dropped faster （36.86±0.72 VS 37.32± 0.81）, the white blood cell count was lower （7.63 ± 2.34 VS 9.08±2.52）, the arterial oxygenation was higher （90.74±9.07 VS 84.88±8.65） and the oxygenation index was higher （308.62±31.67 VS 281.19±33.06）. After 10 days＇ treatment, the rate of infection control was significantly higher in the Mucosolvan joint Ipratropium group （82.9%） than that （62.5%） of the control group. The mean time of infection control was significantly shorter in the Mucosolvan joint Ipratropium group （6.3±2.4） than that （12.8±4.5） of the control group. Conclusions The effect of Mucosolvan joint Ipratropium bromide atomization inhalation in the treatment for patients with pulmonary infection after severe traumatic brain injury is considered being more effective than the treatment with Mucosolvan alone, and it is re