中文摘要：

采用改进的溶胶-凝胶工艺合成了具有纳米介孔结构的硅基干凝胶,并对其止血性能进行了研究.通过X射线衍射（XRD）、红外光谱（FTIR）、透射电镜（TEM）和N_2等温吸附-脱附分析,考察了合成硅基干凝胶的相态、结构、形貌、比表面积和介孔特征.分别采用体外部分凝血活酶时间（APTT）和凝血酶原时间（PT）研究了硅基干凝胶及其加入量对内源性和外源性凝血系统的影响.以传统止血剂云南白药为对比,通过兔耳缘静脉止血实验评价了合成硅基干凝胶的止血性能.结果表明：经600℃煅烧可得到比表面积901.17m^2/g、平均孔径3.255nm的非晶态硅基干凝胶;合成的硅基干凝胶对内、外源性凝血因子活性均有明显的促进作用;硅基干凝胶对兔耳缘静脉止血效果良好,且比云南白药更显著.

英文摘要：

A biodegradable silica-based xerogel with nano-scale mesopores was synthesized by using improved sol-gel process, and its hemostatic properties were investigated. The phase state, chemical structure, surface morphology, specific surface areas and mesoporous structure of the synthesized silicabased xerogels were measured systemically by means of X-ray diffraction （XRD）, infrared spectrum （FTIR）, transmission electron microscope （TEM）, and N2 adsoption-desoption （BET） techniques, respectively. The effects of the silica-based xerogel on intrinsic and extrinsic blood clotting systems were examined through the activated partial thromboplastin time （APTT） and prothrombin time （PT） tests in vitro, respectively. The hemostatic performance of the prepared silica-based xerogel was evaluated at the rabbit＇s ear side veins compared with a traditional hemostatic dressing （Yunnan Baiyao）. The results reveal that the non-crystalline silica-based xerogel with 901.17m^2/g specific surface areas and 3.255nm in apertures is obtained after calcining at 600℃. The silica-based xerogel facilitates both of the intrinsic and extrinsic clotting activities significantly. The silica-based xerogel has good hemostatic effect on the rabbit＇s ear side veins which is better than that of the Yunnan Baiyao.