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蓖麻毒素A链与底物作用的结构基础及其解毒剂的研究进展
  • ISSN号：1674-0440
  • 期刊名称：《国际药学研究杂志》
  • 时间：0
  • 分类：R996.2[医药卫生—毒理学;医药卫生—药学]
  • 作者机构：[1]军事医学科学院基础医学研究所,北京100850
  • 相关基金：国家自然科学基金资助项目（30490240）和国家高技术研究发展规划项目（2003AA002002）
作者： 郭雷鸣（综述）[1], 冯健男[1], （审校）, 黎燕（审校）[1]
关键词： 蓖麻毒素A链, 解毒剂
中文摘要：

蓖麻毒素是从植物蓖麻籽中分离得到的一种Ⅱ型核糖体失活蛋白，其A链（RTA）为效应链，具有N-糖苷酶活性，通过催化28SrRNA在S／R结构域第4 324位脱去一个保守的腺嘌呤，使核糖体60S亚基失活，从而阻断蛋白质合成途径，引起细胞死亡。RTA因其高细胞毒性，常常用于制备免疫毒素药物，尤其在恶性肿瘤的生物治疗上具有诱人的应用前景；或可能被用作恐怖袭击的生物战剂。本文对RTA与底物相互作用的结构信息及其解毒剂进行综述。

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期刊信息
  • 《国际药学研究杂志》
  • 中国科技核心期刊
  • 主管单位:军事医学科学院
  • 主办单位:军事医学科学院毒物药物研究所 中国药学会
  • 主编：刘克良
  • 地址：北京市海淀区太平路27号
  • 邮编：100850
  • 邮箱：gjyxzz@126.com
  • 电话：010-66931618 66931637
  • 国际标准刊号：ISSN：1674-0440
  • 国内统一刊号：ISSN：11-5619/R
  • 邮发代号:82-135
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,美国剑桥科学文摘,中国中国科技核心期刊,中国北大核心期刊（2014版）
  • 被引量:3260