中文摘要：

转化生长因子-β（transforminggrowthfactor-β，TGF-β）作为一种多功能生长因子，具有抑制神经干细胞增殖以及诱导其分化的功能。然而，TGF-β在肿瘤形成过程中具有双重性，在肿瘤形成初期TGF-β可作为抑癌因子抑制细胞增殖．促进细胞分化或凋亡：而在肿瘤发展期，TGF-β却通过促进肿瘤增殖、刺激血管增生和抑制免疫反应而成为促癌因子。目前TGF-β由抑癌因子转变成促癌因子的分子机制尚不清楚。研究发现，TGF-β信号通路在高级别胶质瘤中高度激活表达，并且TGF-β活性高的胶质瘤患者的临床预后极差。胶质瘤干／祖细胞作为胶质瘤发生发展的起源．是胶质瘤治疗成败的关键。因此，研究TGF-β信号通路在胶质瘤干／祖细胞中的生物学效应显得至关重要。本文就TGF-β信号通路在肿瘤干细胞和胶质瘤干／祖细胞的增殖、分化、血管生成、转移等方面的作用作一综述．

英文摘要：

Transforming growth factor β （TGF-β） acting as multifunctional growth factor can inhibit proliferation and induce the differentiation of neural stem cells. However, TGF-β has dual function in the process of tumor formation. TGF-β can be used as tumor suppressor inhibiting cell proliferation, promoting cell differentiation and apoptosis at the early stages of tumor development. While in the stages of tumor progression, TGF-β becomes oncogenic factor stimulating angiogenesis and suppressing the immunoreaction. Although TGF-β signal pathway has been extensively studied, the molecular mechanisms that trigger TGF-β to switch on the transition from tumor- inhibition to tumor-promotion are still not well understood. Recent research suggests that TGF-β signaling is highly active in high grade gliomas and the elevated TGF-~ activity has been associated with poor clinical outcome in this deadly disease. Glioma stem/progenitor cells as the origin of glioma in development, is the key to a successful glioma treatment. Therefore, it is crucial to study TGF-β signaling pathways in glioma stem/progenitor cells （GSPC）. This review summarized the biological effort of the TGF-β signaling pathways in the cancer stem cells and Glioma Stem/ Progenitor Cells including proliferation, differentiation, angiogenesis, and metastasis.