中文摘要：

哺乳动物Notch蛋白包括四种（Notch1～Notch4）,其配体分为两个家族：Jagged家族（Jagged1,Jagged2）和Delta样家族（DLL1,DLL3,DLL4）。Notch信号途径涉及一些蛋白质裂解过程,随后反式作用因子RBP-J及协同激活因子MAML等参与,最终导致靶基因的转录。在早期T细胞发育过程中起关键作用,还调节外周T细胞的活化增殖以及诱导Th细胞亚群的分化。Notch信号途径对转录因子GATA-3激活而诱导的Th2细胞分化非常重要。

英文摘要：

Mammalian Notch proteins （Notchl-Notch4） function as membrane receptors with two kinds of ligands： Jagged family （Jaggedl, Jagged2） and Delta-like family （DLL1, DLL3, DLL4）. Notch signaling is involved in processes of protein cleavage. The components of the signal pathway consist of some special trans-acting factors and co-activators such as mastermind-like 1 （MAML1）, which result in transcription of target genes Hes, Hey and Deltex. Notch proteins play critical role not only in early development of T cell lineage, but also in activation and proliferation of peripheral T cells, as well as in differentiation of Th subsets. Notch signaling is especially crucial for Th2 differentiation via activation of transcription factor GATA-3.