以依达拉奉,丙酮酸和亚磺酸钠为原料,合成了依达拉奉衍生物2-(1-苯基-3-甲基-5-氧代-4-吡唑基)-2-磺基丙酸,总收率54%,纯度〉99.9%,其结构经^1H NMR,^13C NMR和HR-MS确证。
2-( 3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-2-sulfopropanoic acid( purity 99. 9%),in total yield of 54%,was synthesised by the reaction of edaravone,pyruvic acid and sodiumhydrogensulfite. The structure was confirmed by^1 H NMR,^13 C NMR and HR-MS.