中文摘要：

目的：探讨脑源性神经营养因子（BDNF）rs6265和儿茶酚胺氧位甲基转移酶（COMT）rs4680的多态性与广西壮族散发性帕金森病（PD）的相关性。方法：使用PCR-RFLP法对112例壮族散发性PD患者的rs6265和rs4680位点进行基因分型,并与156例健康壮族老年人比较,分析这两个多态与PD的相关性。结果：除PD早发亚组rs6265基因型GG的频率高于同年龄段对照组（P〈0.05）,两组间的等位基因及基因型频率均无统计学差异（P〉0.05）。两位点A等位基因罹患PD的风险与正常人群无异,OR分别为1.212（P=0.572）和0.985（P=0.427）。结论：rs6265和rs4680与广西壮族散发性PD的遗传易感缺乏关联性。

英文摘要：

Objectives：To investigate the correlation between BDNF rs6265 and COMT rs4680 on sporadic Parkinson＇s disease（PD）in Zhuangs.Methods：PCR-RFLP was employed to genotype rs6265 and rs4680for112sporadic PD patients and 156 controls.Results：No difference on allelic and genotypic frequencies was found between the two groups（all P〉0.05）under any genetic models except that the GG genotype of rs6265 was higher in the early-onset PD subgroup as compared to controls（P〈0.05）.Similar PD risk for A and non-A allele carriers was found on both SNP（rs6265：OR = 1.212,P = 0.572;rs4680：OR = 0.985,P = 0.427）.Conclusions：No association between rs6265 and rs4680and the susceptibility of sporadic PD in Zhuangs.