欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
人工设计的核酸酶是目前进行精确基因组修饰的有效工具之一，在生命科学基础研究和人类遗传疾病的治疗研究领域有着广泛的应用价值。有必要综述转录激活因子样效应物核酸酶（transcription activator-like effector nucleases，TALEN）的技术背景，以及其应用研究基础上的核酸酶活性和特异性，并探讨TALEN用于靶向基因组修饰过程中所存在的一些问题。
英文摘要：
Custom-designed nucleases have become an effective tool for precise modification of complex genomes which have been widely used for basic research in life science and gene therapy for human genetic disease. It is necessary to summarize the technological background, the activity and specificity of transcription activator-like effector nucleases （TALENs） for applied research, and further discuss the existing problems during the process used for targeted genome modification.
同期刊论文项目
同项目期刊论文
A novel system for rapid screening of effective siRNA target sites by one step transfection with a s
A novel vector for a rapid generation of fiber-mutant adenovirus based on one step ligation and quic
A fiber chimeric CRAd vector Ad5/11-D24 double-armed with TRAIL and arresten for enhanced glioblasto
期刊信息
位置：