中文摘要：

背景 Apelin 是贡献类型 2 糖尿病的致病的 adipokine。apelin 的血浆层次在肥胖的病人和糖尿病的题目增加了。这研究试图调查 apelin 的效果类型 2 糖尿病和我们选择了的相关量的 traits.Methods 上的基因变体能在 APLN 基因区域和 genotyped 捕获所有普通变体的三单个核苷酸多型性(SNP ) 他们在 1892 类型 2 个糖尿病的病人和 1808 正常葡萄糖规定控制。与葡萄糖新陈代谢有关的临床的特征在控制被测量。在情况和控制中的等位基因和遗传型分发的比较被使用 X2 测试执行。在 SNP 和量的特点之间的协会用 Wilcoxon 任何一个都没 SNP 或 haplotypes 显示出的等级和 test.Results 被分析到类型 2 糖尿病的协会的证据。然而， rs2235306 有名无实地与正常葡萄糖规定在男题目与 fasting 血浆葡萄糖层次被联系((4.93 吗？

英文摘要：

Background Apelin is an adipokine that contributes to the pathogenesis of type 2 diabetes. The plasma levels of apelin increased in obese patients and diabetic subjects. This study aimed to investigate the effects of apelin genetic variants on type 2 diabetes and related quantitative traits. Methods We selected three single nucleotide polymorphisms （SNPs） that could capture all common variants in APLN gene region and genotyped them in 1892 type 2 diabetic patients and 1808 normal glucose regulation controls. The clinical features related to glucose metabolism were measured in the controls. The comparison of allele and genotype distribution in the cases and controls were performed by using X2 tests. The association between SNPs and quantitative traits were analyzed using Wilcoxon＇s rank-sum test. Results None of the SNPs or haplotypes showed evidence of association to type 2 diabetes. However, rs2235306 was nominally associated with fasting plasma glucose levels in the male subjects with normal glucose regulation （（4.93±0.03） vs （5.01±0.03） mmol/L, P=0.04）. No significant difference was observed between all three SNPs and other variables. Conclusions APLN SNP rs2235306 was associated with fasting plasma glucose levels in males. It suggests that APLN genetic variants may contribute to clinical features related to glucose metabolism in Chinese population.