中文摘要：

肝细胞担负大量的代谢功能，包括脂肪酸的合成与类固醇的代谢。内质网应激反应（ERstressresponse）作为内质网中特殊的机制用以保证内质网内部的稳态和功能正常。有研究指出内质网应激诱导的信号通路及其通路上的关键蛋白参与肝细胞的脂类代谢过程。本文主要讨论内质网应激反应影响肝细胞脂类代谢的机制，以及内质网应激与脂类代谢紊乱疾病的相关性。

英文摘要：

Hepatocytes take on a lot of function in metabolism, including fatty acid synthesis and cholesterol metabolism. Endo- plasmic reticulum stress （ER stress） is known as the adaptive mechanism that keep Endoplasmic reticulum homeostasis and normal func- tion. Some researches showed that the ER stress signalling pathway and key proteins in signalling pathway were involved in lipid metabolism. This paper will focus on the mechanism of ER stress induced-signaling on lipid metabolism and the relationship between ER stress and the diseaseinduecd by lipid metabolic disorder.