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Oscillatory and anti-oscillatory motifs in genetic regulatory networks
  • ISSN号：1674-1056
  • 期刊名称：《中国物理B：英文版》
  • 时间：0
  • 分类：O175.7[理学—数学;理学—基础数学] Q253[生物学—细胞生物学]
  • 作者机构：[1]Department of Systems Science, School of Management and Center for Complexity Research, Beijing Normal University, Beijing 100875, China, [2]Department of Physics, Beijing Normal University, Beijing 100875, China, [3]General Research Institute for Nonferrous Metals, and Grirem Advanced Materials Co. Ltd., Beijing 100088, China
  • 相关基金：Project supported by the National Natural Science Foundation of China （Grant No. 10975015） and the National Basic Research Program of China （Grant No. 2007CB814800）.
作者： 叶纬明[1], 张朝阳[2], 吕彬彬[3], 狄增如[1], 胡岗[2], 刘东[1], 银振强[1], 王双[1], 王粉梅[1], 陈巍[1], 韩正甫[1]
关键词： 基因调控网络, 振动性, 图案, 持续振荡, 波动, 生物领域, 抑制效果, 抗振动, genetic regulatory network, oscillatory motif, anti-oscillatory motif, feedback loop
中文摘要：

Recently,self-sustained oscillatory genetic regulatory networks(GRNs) have attracted significant attention in the biological field.Given a GRN,it is important to anticipate whether the network could generate oscillation with proper parameters,and what the key ingredients for the oscillation are.In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered.In particular,some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed.Moreover,there are some anti-oscillatory motifs which have a strong oscillation repressing effect.Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.

英文摘要：

Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.

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期刊信息
  • 《中国物理B：英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国物理学会和中国科学院物理研究所
  • 主编：欧阳钟灿
  • 地址：北京 中关村 中国科学院物理研究所内
  • 邮编：100080
  • 邮箱：
  • 电话：010-82649026 82649519
  • 国际标准刊号：ISSN：1674-1056
  • 国内统一刊号：ISSN：11-5639/O4
  • 邮发代号:
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  • 国内外数据库收录:
  • 被引量:406