中文摘要：

目的 建立中国汉族正常成人扣带回体积的正常值范围,探讨扣带回体积与年龄的相关关系,为中国成人数字标准脑提供基础性数据.方法 采用全国多中心临床研究形式,选取1000名中国健康成年志愿者,按年龄18～30、31～40、41～50、51～60、61～70岁分为A、B、C、D、E组,每组男、女各100名,行大脑3D磁化强度预备梯度回波序列T1WI,应用3D体积分析软件测量扣带回的体积.不同年龄组扣带回体积的比较采用方差分析,不同性别、侧别扣带回体积的比较采用配对样本t检验,扣带回体积与年龄进行相关与回归分析.结果 男、女扣带回总体积分别为（20 347±2504）、（19 432±2184）mm^3,差异有统计学意义（方差不齐,采用两组独立样本t＇检验,t＇=6.156,P〈0.05）,男性扣带回总体积大于女性.男性左、右侧扣带回体积分别为（9630±1498）、（10 717±1629）mm3,女性分别为（9368±1441）、（10064±1407）mm^3,男、女不同侧别扣带回体积比较差异均有统计学意义（t值分别为-12.960、-8.511,P值均〈0.05）,右侧扣带回体积均大于左侧.男性A、B、C、D、E组扣带回体积：左侧分别为（10 132±1291）、（10 113±1638）、（9599±1576）、（9594 ±1288）、（8710 ±1212）mm^3,右侧分别为（11 212±1442）、（11 096±1602）、（11 040 ±1403）、（10 633±1638）、（9604 ±1522）mm^3,不同年龄组间差异有统计学意义（F值分别为16.738、18.707,P值均〈0.01）.女性A、B、C、D、E组扣带回体积：左侧分别为（9689 ±1426）、（9652±1676）、（9347±1500）、（9098±1225）、（9053±1233）mm^3,右侧分别为（10 558 ±1325）、（10 266 ±1463）、（10 100±1497）、（9779±1304）、（9617±1254）mm^3,不同年龄组间差异有统计学意义（F值分别为16.859、7.528,P值均〈0.01）.男、女双侧扣带回体积与年龄均存在负相关（r值分别为-0.330、-0.324、-0.169、-0.243,P值均〈0.05）,但相关

英文摘要：

Objective To explore the normal range of cingulate cortex volumes of Chinese adults of the Han nationality and its relationship with age, which provide morphological data for the construction of database for Chinese Standard Brain.Methods This is a clinical multi-center study.One thousand Chinese healthy volunteers （ age range = 18 to 70） recruited from 15 hospitals were divided into 5 groups, i.e.,Group A （age range = 18 to 30）, B （age range=31 to 40）, C （age range =41 to 50）, D （age range =51 to 60）, and E （age range =61 to 70）.Each group contained 100 males and 100 females.All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence.Cingulate cortex volume （including bulk volume and the left/right volume） was measured semi-manually using 3D volume analysis software.Cingulate cortex volumes among age groups were compared by one-way ANOVA.Right and left cingnlate cortex volumes between sexualities were analyzed by paired samples t test.The relationship between cingulate cortex volume and age was analyzed by Pearson correlations and regression analysis.Results Cingulate cortex volumes of male and female were （20 347 ± 2504） and （ 19 432 ± 2184） mm^3 respectively, and the male＇s was significantly larger than that of female＇s （two sample t＇-test for independent samples, t＇= 6.156, P 〈 0.05 ）.Right and left cingnlate cortex volumes of male were （ 10 717 ± 1629） and （9630 ± 1498） mm^3 respectively, and those of female＇s were （ 10 064 ± 1407 ） and （ 9368 ± 1441 ）mm^3 respectively.The volumes of cingulate cortex were significantly different between right and left in male or female （ t = - 12.960, - 8.511, P 〈 0.05 ）,and right was larger than left.Bilateral cingulate cortex volume in male among group A, B, C, D and E[left： （ 10 132 ± 1291 ）, （ 10 113 ± 1638）, （9599 ± 1576）, （9594 ± 1288）, （8710 ± 1212） mm^3 ; right：（11 212±1442）,