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Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae
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  • 分类:X171[环境科学与工程—环境科学] S968.323[农业科学—水产养殖;农业科学—水产科学]
  • 作者机构:[1]School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, China, [2]Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China, [3]Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China, [4]Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, Gansu, China, [5]Gansu Medicinal College, Pingliang 744000, Gansu, China, [6]Lanzhou veolia Water(Group) Co., Ltd, Lanzhou 730000, Gansu, China
  • 相关基金:National Basic Research Program of China (2010CB834202); the National Natural Science Foundation of China (11305226, 11175222); the Scientific Technology Research Projects of Lanzhou City (2015-3-75); and the Western Talent Program of Chinese Academy of Sciences (Y460030XBO).
中文摘要:

<正>The use of exogenous carbon monoxide releasing molecules(CORMs)provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.CORM-3

英文摘要:

The use of exogenous carbon monoxide releasing molecules(CORMs)provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.

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