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κ-阿片肽在低氧性肺动脉高压形成中的作用
  • 期刊名称：现代生物医学进展
  • 时间：0
  • 页码：3546-3549
  • 语言：中文
  • 分类：R563.3[医药卫生—呼吸系统;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构：[1]第四军医大学口腔医学系九队,陕西西安710032, [2]第四军医大学药学系一队,陕西西安710032, [3]第四军医大学基础生理学教研室,陕西西安710032, [4]第四军医大学西京医院儿科,陕西西安710032
  • 相关基金：国家自然科学基金（NO：30700345,30770802,30971060,30900535）
  • 相关项目：k-阿片受体通过调节缝隙连接蛋白Cx43参与抗缺血性心律失常的研究
作者： 李娟|李国瑞|肖维维|裴建明|孙新|李新方|
关键词： Κ阿片受体, κ阿片肽, 低氧性肺动脉高压, 离子通道, κ-Opioid receptor, κ-Opioid, hypoxic pulmonary hypertension, ion channel.
中文摘要：

低氧性肺动脉高压（hypoxic pulmonary hypertension,HPH）是慢性阻塞性肺病、慢性高原病和新生儿肺病等临床众多心、肺疾病发病的重要的生理环节,其形成机制尚不完全清楚,防治也不十分理想。低氧性肺血管收缩反应（hypoxic pulmonary vaso-constriction,HPV）和肺血管结构重建（pulmonary artery remodeling,PAR）是HPH的两个主要发病环节,而肺动脉平滑肌细胞（pul-monary arterial smooth musclecell,PASMC）内的钙稳态及膜离子通道,尤其是钙通道和钾通道活性的改变在其中又发挥了非常重要的作用。近年来关于κ-阿片肽对HPH的影响机制有一些研究。本文就其研究进展作一综述。

英文摘要：

Hypoxic pulmonary hypertension （HPH） is an important pathophysiological stage in the genesis and development of many cardiovascular diseases and pulmonary diseases. However, the pathogenesis of HPH has not been elucidated thoroughly, and there is still no ideal therapeutic strategy for HPH. Hypoxic pulmonary vasoconstriction （HPV） and pulmonary artery remodeling （PAR） play an important role in HPH, There are many factors involved in HPH which including calcium homeostasis, especially changes of activity in calcium channel and potassium channel. Recently, there are some researches about the effect of κ-opioid peptide on HPH and its underly mechanism. Here, we will review the progress of the researches.

同期刊论文项目
κ-阿片受体通过调节内皮素及其受体信号通路参与抗缺血性心律失常的研究
期刊论文 37 会议论文 10 著作 1
κ-阿片肽对低氧性肺动脉高压大鼠血管内皮功能改善作用及其机制研究
期刊论文 24 会议论文 5
k-阿片受体通过调节缝隙连接蛋白Cx43参与抗缺血性心律失常的研究
期刊论文 36 会议论文 8 著作 4
κ-阿片肽对低氧性肺动脉高压的防治作用及其离子机制
期刊论文 10
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