中文摘要：

放射性核素报告基因显像技术作为监测基因治疗表达的一种有效手段，是目前研究的热点。报告基因系统主要有三类，其中酶的报告基因系统中的单纯疱疹病毒1-胸苷激酶由于其良好的理化特性，适合作为报告基因而对其进行了深入、广泛的研究，它的两类底物是嘌呤核苷衍生物和无环鸟苷衍生物，目前已经用不同放射性核素进行标记而达到显像目的。

英文摘要：

Radionuclide reporter gene imaging is an effect way to provide qualitative and quantitative information for gene therapy. There are three systems of reporter gcne including kinase reporter gene. perpes simplex virus type 1-thymidine kinase （HSV1-tk） has perfect physical and chemical characteristic which is suit for imaging as reporter gene. It has been widely investigated and intensively researched. Two substrates of HSV1-tk are purine nucleosite derivant and acyclovir derivant, which can also be used as reporter probes of HSV1-tk.