中文摘要：

白介素-2（interleukin-2,IL-2）是最早发现并应用于临床的细胞因子之一。最初IL-2因具有刺激T细胞增殖的能力引人关注,随后更多研究发现IL-2主要通过结合IL-2受体（interleukin-2 recepter,IL-2R）激活下游信号通路改变调节性T细胞（regulatory T cells,Tregs）与效应性T细胞（effector T cells,Teffs）间的比例,维持免疫耐受,实现人为调节免疫介导疾病的过程。近年来,IL-2在自身免疫性疾病、肿瘤免疫及器官移植耐受诱导中具有广泛的应用前景而备受瞩目。本文主要对IL-2和IL-2受体、其信号传导通路及免疫治疗作用做一综述。

英文摘要：

IL-2 is one of the earliest cytokines discovered and applied in clinical medicine. At the first time,IL-2 drew much attention because of its ability to stimulate the proliferation of T cells. Posterior studies revealedthat IL-2 can shift the balance between Tregs and Teffs by activating downstream signaling through the combinationwith receptor IL-2R. The shifted balance of Tregs and Teffs could maintain the immune tolerance and thus changethe course of immune-mediated diseases. Recently, with further research on biological activity of IL-2, scientistsre-evaluate the indications, application dose, security, as well as immunotherapeutic effect of IL-2.