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隔核在海马Ghrelin调控学习记忆中的作用

ISSN号：1672-4488
期刊名称：青岛大学医学院学报
时间：2011
页码：474-476
分类：R338.64[医药卫生—人体生理学;医药卫生—基础医学]
作者机构：[1]青岛大学医学院病理生理学教研室,山东青岛266021, [2]莱芜市中医医院儿科
相关基金：国家自然科学基金项目（30470642,30670780,31071014和81070305）; 山东省科技攻关项目（2008GG10002006）; 山东省卫生厅资助项目（2007HZ026）; 青岛市科技局资助项目（05-1-JC-93）
相关项目：情绪相关中枢与下丘脑ghrelin能神经通路构成及对胃运动和能量摄取调控研究

作者：刘艳|徐珞|

关键词： GHRELIN, 隔核, 海马, 学习, 记忆, 大鼠, Ghrelin, septal nuclei, hippocampus, learning, memory, rats

中文摘要：

目的观察大鼠隔核毁损后海马注射Ghrelin对学习记忆能力的影响。方法采用立体定向电极毁损大鼠隔核,海马CA2-3区微量注射Ghrelin,利用跳台实验及Morris水迷宫进行定位航行实验和空间搜索实验。结果海马CA2-3区注射Ghrelin可明显增强大鼠学习记忆能力,表现为跳台实验中大鼠从安全台跳下的潜伏期明显延长（t=8.17,P〈0.05）,5min内大鼠遭受电击次数明显减少（t=7.72,P〈0.05）,Morris水迷宫实验中大鼠找到平台的潜伏期明显缩短（t=7.35,P〈0.01）。隔核毁损后,跳台实验中大鼠从安全台跳下的潜伏期则明显缩短（t=7.08,P〈0.05）,5min内大鼠遭受电击次数明显增加（t=9.81,P〈0.01）,Morris水迷宫实验中大鼠找到平台的潜伏期明显延长（t=7.29,P〈0.01）。结论海马CA2-3区注射Ghrelin可提高大鼠学习记忆能力,而该作用可能与隔核-海马通路有关。

英文摘要：

Objective To explore the effect and mechanism of Ghrelin on ability of learning and memory in septal-nucleus-damaged rats.Methods The septal nucleus was destructed by direct current using stereotactic technique.Step-down test and Morris water maze were used to test the effects of ability of learning and memory by means of microinjection of Ghrelin into hip-pocampal CA2-3 area in rats.Results Ghrelin injection in CA2-3 area of hippocampus obviously increased the rats＇ ability of learning and memory,manifesting prolonged latent period of jumping down form refuge platform（t=8.17,P0.05）,and the numbers of subjecting electric shock in 5 minutes obviously decreased（t=7.72,P0.05）;the latency of finding the platform was significantly shortened in Morris water maze test（t=7.35,P0.01）.After impairment of the septal nucleus,the latency period of jumping down from refuge platform was shortened（t=7.08,P0.05）,the numbers of electric shock within 5 minutes increased（t=9.81,P0.01）,and the time of finding the platform prolonged in Morris water maze（t=7.29,P0.01）.Conclusion An injection of Ghrelin in CA2-3 area of hippocampus in rats can raise their ability of learning and memory,which is likely to be associated with the septal-hippocampus pathway.

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