中文摘要：

Many studies have reported the relationship between CXCL12 G801 A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. Pub Med and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios(ORs) with 95% confidence intervals(95% CIs) were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found(A vs. G: OR=1.26, 95% CI=1.13–1.40, P<0.01; AA+AG vs. GG: OR=1.33, 95% CI=1.16–1.52, P<0.01). In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations(for Asian, AA+AG vs. GG: OR=1.74, 95% CI=1.22–2.47, P<0.01; for Caucasian, AA+AG vs. GG: OR=1.24, 95% CI=1.09–1.42, P<0.01). Our result indicated that CXCL12 G801 A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted.

英文摘要：

Many studies have reported the relationship between CXCL12 G801 A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. Pub Med and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios（ORs） with 95% confidence intervals（95% CIs） were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found（A vs. G： OR=1.26, 95% CI=1.13-1.40, P〈0.01; AA＋AG vs. GG： OR=1.33, 95% CI=1.16-1.52, P〈0.01）. In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations（for Asian, AA＋AG vs. GG： OR=1.74, 95% CI=1.22-2.47, P〈0.01; for Caucasian, AA＋AG vs. GG： OR=1.24, 95% CI=1.09-1.42, P〈0.01）. Our result indicated that CXCL12 G801 A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted.