中文摘要：

模拟5km急性低氧2h、4h、8h和24h，观察大鼠海马白介素-6（IL-6）和低氧诱导因子-1（HIF-1α）表达的时序变化．分别运用免疫组化和RT-PCR分析海马CA1、CA2和CA3区IL-6、HIF-1α和海马HIF-1α mRNA的表达水平．与对照组相比，5km急性低氧8h和24h，海马CA1区IL-6水平升高14．24％（P〈0．01）和7．76％（P〈0．05）；低氧8h，海马CA2和CA3区IL-6水平上升3．1％（P〈0．05）和5．1％（P〈0．05）．5km低氧4h、8h和24h，海马CA1区HIF-1α水平分别升高3．67％（P〈0．05）、5．5％（P〈0．05）和6．27％（P〈0．01），同时发现HIF-1α mRNA在海马的表达上调．上述结果表明，5km急性低氧促进海马IL-6和HIF-1α的表达增强，推测HIF-1α能作为调控因子参与低氧下海马IL-6的诱导表达．图5表1参21

英文摘要：

Interleukin-6 （IL-6） and hypoxia-inducible factor 1α （HIF-1α） expressions in hippocamus of rats were studied, exposing to 5 km acute hypoxia for 2 h , 4 h, 8 h and 24 h. The expressions of IL-6 and HIF-1α in hippocampus were analyzed by immunocytochemistry, while that of HIF-1α mRNA by RT-PCR. 5 km acute hypoxia for 8 h and 24 h increased the expres- sion of IL-6 in hippocampus CA1 by 14.24% （ P 〈 0.01 ） and 7.76% （P 〈 0.05）, respectively. 5 km acute hypoxia for 8 h increased the expressions of IL-6 in hippocampus CA2 and CA3 by 3.1% （ P 〈 0.05） and 5.1% （P 〈 0.05）, respectively. 5 km acute hypoxia for 4 h, 8 h and 24 h enhanced the expressions of HIF-1α in hippocampus CA1 by 3.67% （P 〈 0.01 ）, 5.5% （P 〈0.05） and 6.27% （ P 〈 0.01 ）, and increased HIF-1α mRNA expression in hippocampus. The results showed that acute hypoxia induced HIF-1α and IL-6 expressions in hippocampus. It indicated that HIF-1α might regulate IL-6 expression under acute hypoxia. Fig 5, Tab 1, Ref 21