中文摘要：

在利用核小体定位实验数据训练支持向量机（SVM）对任意酵母DNA序列的核小体形成能力进行预测的过程中，发现染色质结构对基因组DNA分子进化过程有着显著影响。我们观察到核小体DNA比连接DNA的平均预测准确率低15％，这种普遍存在的局部预测准确率差异性代表了酵母核小体定位的进化印迹（Evolutionary footprint），它揭示了核小体组织在基因组的整个进化过程中所具有的保守性。

英文摘要：

When we used DNA sequences of Saccharomyces cerevisiae whose nucleosome positioning data have been experimentally determined to train a support vector machine to predict the nucleosome formation potential of any given sequence of DNA, we observed that chromatin structure has an impact on the evolution of genomic DNA mol- ecules. We have found, on average, 15% lower predictive accuracy rates in nueleosomal DNA than in linker DNA. This widespread local rates heterogeneity represents an evolutionary footprint of nueleosome positions and re- veals that nucleosome organization is a genomic feature conserved over evolutionary timescales.