中文摘要：

GATA-1是重要的转录调控因子，主要功能是上调红细胞系统相关基因的转录，同时抑制与细胞增殖分裂等相关基因的表达，在红细胞分化过程中发挥着重要作用。GATA-1在红细胞分化中的作用主要是通过对β-珠蛋白基因的调控来实现的。这一作用涉及到了多种辅助因子，这些因子在不同发育时期以多种形式参与β-珠蛋白基因的转录调控。

英文摘要：

GATA-1 is a critical transcription factor which is essential for erythroid differentiation. GATA- 1 induces erythroid differentiation through both activation and repression, of erythroid related and proliferation related genes expression. Different transcription factors and cofactors are recruited by GATA-1 to perform the dual functions of regulation. A specific example is that protein-protein interactions between GATA-1 and cofactors are involved in regulation on β-globin gene： they activate transcription by binding at specific cis-regulatory elements at specific stage. In this review, we focus on multiple cofactors cooperating with GATA-1 at different period to activate or repress specific genes which would promote erythroid differentiation.