呋喃并喹啉结构单元广泛存在于很多天然产物中.介绍一种在加热的条件下,三氟甲磺酸促进的,通过多取代呋喃衍生物分子内环合反应制备呋喃[2,3-b]喹啉类化合物的方法.该方法具有操作简单、官能团兼容性好、区域选择性好和产品产率较高等优点.
The furoquinoline unit is present in many natural products. Here, an approach is presented for the preparing of furo[2,3-b]quinolines from readily available multi-substituted furans in the presence of Br?nsted acid via an intramolecular cyclization under the heating conditions. Simple operation, good compatibility, high regioselectivity and morderate yields are the advantages of the method.