东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Asymmetric synthesis of α-aminophosphonates by means of direct organocatalytic three-component hydrophosphonylation

分类：O621.34[理学—有机化学;理学—化学] O627.51[理学—有机化学;理学—化学]
作者机构：[1]Department of Chemistry, Tianjin University, Tianjin 300072, China, [2]Department of Chemistry, Henan Agricultural University, Zhengzhou 450002, China
相关基金：This work was supported by the National Natural Science Foundation of China （20772091） and Tianjin Municipal Science and Technology Commission （07JCZDJC04700）.

作者： WANG Lian[1], CUI ShuMin[2], MENG Wei[1], ZHANG GuangWu[1], NIE Jing[1], MA JunAn[1]

关键词：不对称合成, Α-氨基膦酸酯, 三组分, 有机催化, 对映选择性, 亚磷酸酯, 手性, 醛, Ф-aminophosphonate, organocatalysis, aromatic aldehyde, three-component reaction, enantioselectivity

中文摘要：

直接不对称的三部件的反应一芳香(或苯乙烯) 醛，胺和亚磷酸盐被采用 chiral Br 调查 ? nsted 酸。一般来说，对好 enantioselectivities (31%87% ee ) 谦虚能为一系列底层在可接受的孤立的收益(61%91%) 被获得。

英文摘要：

The direct asymmetric three-component reaction of an aromatic （or cinnamic） aldehyde, an amine and a phosphite was investigated by employing chiral BrФnsted acid. In general, modest to good enantioselectivities （31%-87% ee） could be obtained in acceptable isolated yields （61%-91%） for a series of substrates.