中文摘要：

<正>Continuous efforts have been made to identify molecular markers for the prognosis of gastric cancer,the second leading cause of cancer death accounting for 10%of cancer mortality worldwide(Ferlay et al.,2010;Chen et al.,2013).Studies using candidate gene approach,GWAS(genome-wide association study),and expression profiling have reported markers significantly associated with gastric cancer survival(Luo et al.,

英文摘要：

Continuous efforts have been made to identify molecular markers for the prognosis of gastric cancer, the second leading cause of cancer death accounting for 10% of cancer mortality worldwide （Ferlay et al., 2010; Chen et al., 2013）. Studies using candidate gene approach, GWAS （genome-wide asso- ciation study）, and expression profiling have reported markers significantly associated with gastric cancer survival （Luo et al., 2011; Kang et al., 2014; Song et al., 2014）, and these markers have contributed to the clinical prediction of patients＇ outcome. However, gastric cancer is a highly heterogeneous disease etiologically, clinically, and pathologically. In this sense, it is plausible that single markers like DNA sequence variation, or gene/microRNA expression cannot fully reflect the heterogeneous survival of gastric cancer.