中文摘要：

目的探究水囊联合不同剂量雌激素辅助治疗宫腔镜术后宫腔粘连的疗效、1年妊娠率及预后效果。方法采用回顾性分析的方法,对2014年10月-2016年10月在惠州市第二妇幼保健院接受治疗的60例宫腔镜术后宫腔粘连患者的临床资料进行分析,根据术后雌激素给药剂量的不同将患者分为低剂量组（4 mg/d,30例）和高剂量组（12 mg/d,30例）,并对两组患者的临床治疗效果、1年妊娠率及预后情况进行综合评价。结果高剂量组患者治疗总有效率高于低剂量组,差异有统计学意义（P〈0.05）。高剂量组患者1年妊娠率略高于低剂量组,但差异无统计学意义（P〉0.05）。治疗前,两组患者子宫内膜厚度比较,差异无统计学意义（P〉0.05）;经过不同方式的治疗,高剂量组患者子宫内膜厚度显著高于低剂量组,差异有统计学意义（P〈0.05）。结论对宫腔镜术后宫腔粘连患者给予水囊联合高剂量雌激素辅助治疗,对再次妊娠无明显影响,可有效改善宫腔镜术后宫腔粘连,促进子宫内膜恢复。

英文摘要：

Objective To explore the curative effect of water balloon combined with different doses of estrogen in treatment of intrauterine adhesion after hysteroscopy,1-year pregnancy rate and prognostic effect. Methods The clinical data of 60 patients with intrauterine adhesion after hysteroscopy in the hospital from October 2014 to October 2016 were analyzed retrospectively. According to the dose of postoperative estrogen,the patients were divided into low-dose group（ 4 mg/d） and high-dose group（ 12 mg/d）,30 patients in each group. The curative effects,1-year pregnancy rates,and prognostic effects in the two groups were evaluated comprehensively. Results The overall response rate in high-dose group was statistically significantly higher than that in low-dose group（ P〈0. 05）. The one-year pregnancy rate in high-dose group was slightly higher than that in low-dose group,but there was no statistically significant difference（ P〉0. 05）. Before treatment,the endometrial thickness between the two groups had no statistically significant difference（ P〉0. 05）. After different treatments,the endometrial thickness between the two groups had statistically significant difference（ P〈0. 05）. Conclusion Water balloon combined with high-dose estrogen in treatment of intrauterine adhesion after hysteroscopy has no significant effect on re-pregnancy,but it can effectively improve intrauterine adhesion after hysteroscopy and promote the recovery of endometrium.